Endocrine Abstracts

Some patients with pituitary adenomas show high CSF levels and/or high CSF/serum ratio for peptidic pituitary hormones (PR), potentially due to a blood-brain barrier (BBB) damage. We evaluated albumin.CSF/serum ratio (AR) in patients with pituitary adenomas and elevated PR, as an accurate index for a BBB damage.Patients and methods: We evaluated 10 controls (21–79 years, 6M /4 F) before undergoing abdominal or peripheral surgery and 52 patients with...

Pituitary apoplexy is a rare syndrome due to a clinically overt hemorrhagic infarction, described in 2–7% of pituitary adenomas. A subclinical usually asymptomatic pituitary hemorrhage and/or infarction may be detected on routine imaging or during histopathological examination in 25–28% of patients with pituitary adenomas.Aim: We compared the clinical features and evolution of 166 patients with subclinical pituitary apoplexy (SPA) and 46 patien...

Graves’ disease (GD) and Hashimoto’s thyroiditis (HT) are both autoimmune thyroid diseases. While transition from GD to hypothyroidism has been more frequently reported, conversion of hypothyroidism to GD is uncommon. We describe a series of 3 patients diagnosed with HT and hypothyroidism, treated with L-thyroxine (LT4), who developed persistent hyperthyroidism with increased thyrotropin receptor antibodies (TRAb) levels and, in two of the patients, Graves’ opht...

BIOMAT-ENDO software is a Windows Forms application that stores all the main data regarding the patients with thyroid cancer (TC) hospitalized in the Nuclear Medicine Department of the National Institute of Endocrinology in Bucharest, starting with the first hospitalization, continuing with the periods of radioiodine therapy (RIT) and the follow up. Patient-monitoring MODULE contains clinical parameters, surgery details, in Vivo and in Vitro investig...

IntroductionAnti-thyroid drugs (ATDs) are the first line treatment in Europe for hyperthyroidism due to Graves’ disease (GD). Adding levothyroxine to ATDs, so called block and replace therapy (BRT) is still controversial.AimTo follow up the outcomes after treating patients with Graves’ disease in a block and replace regimen.Patients & methodsA prospe...

BackgroundLymphocytic hypophysitis is an unusual inflammation of the pituitary gland affecting mostly women. Its pathogenesis is still poorly understood and the presentation and clinical course vary largely. Serum prolactin levels may be low, normal, or elevated. Unlike what is observed in clinically nonfunctioning pituitary adenomas, there is not a clear hierarchy of anterior pituitary hormone deficiencies. Hypophysitismay resolve spontaneously, may rel...

IntroductionThyrotoxicosis debuted early after thyroid lobectomy is described in approximately 54% of cases. It has also been described in a few case reports after non thyroid neck surgeries or in invasive laryngeal cancer after total laryngectomy and debulking hemithyroidectomy.Case presentationPatient aged 53 years old, known with laryngeal carcinoma of 37/28/40 mm located at piriform sinus, linked by the l...

Introduction: New-onset hyperandrogenism is rare in postmenopausal women and is usually associated with causes such as ovarian hyperthecosis, androgen-secreting tumor or medication. Patients with hyperandrogenism and breast cancer need a special attention when choosing the treatment.Case history: A 46-year old woman diagnosed with hormone receptor-positive breast cancer at 37 years old, for which she underwent surgery, chemotherapy, radiotherapy and horm...

New possible pathogenic variants involved in pheochromocytomas and paragangliomasIntroduction: Pheochromocytomas and paragangliomas (PPGLs) are rare tumors of the chromaffin tissues that store and release catecholamines in excess. Most pheochromocytomas are sporadic, usually resulting in unilateral adrenal tumor, but 25–45% harbour a germline mutation.Aim: To describe new possible pathogenic variants (VUS) involved in PPGLs.</...

Introduction: Treatment options for acromegaly include surgery or radiation to remove or reduce the size of the tumor and medication to help normalize the hormone levels. While improving the prognosis, patients with acromegaly treated with radiotherapy are at risk of long-term development of secondary malignancies (1-2% at 10-20 years). We report the case of a 55-year old woman diagnosed with high-grade sarcoma of the sphenoid sinus developed 34 years after receiving 60Cobalt ...